專業團隊


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周邊血液幹細胞專職醫檢師 李如璧

周邊血液幹細胞專職醫檢師 李如璧

周邊血液幹細胞專職醫檢師 李如璧

學歷

國立清華大學 生命科學系 博士

專長

分子檢驗醫學、細胞與分子生物學、血液與免疫相關疾病研究

經歷

國立清華大學 生命科學系 博士後研究員

國家衛生研究院 免疫醫學研究中心 博士後研究員

國防醫學院 牙醫學系暨牙醫科學研究所 兼任助理教授

中國醫藥大學附設醫院 風濕病研究中心 助理研究員

中山醫學大學 醫學系 助理教授

中山醫學大學附設醫院 醫檢師/兒童血液腫瘤治療團隊

證照

2019 SCRS Ambassador Taiwan Symposium -Moving Beyond Excellence: Outstanding Taiwan Clinical Trial in the Next Decade (臨人訓字第10835040號)

移植免疫學 (中山附醫證字第11001310006-161號)

全球臨床試驗國際趨勢 (中山附醫證字第11001310012-135號)

中山醫學大學附設醫院及臺中榮民總醫院血液腫瘤科聯合訓練計畫 (中榮教字第1092900329號)

醫事檢驗臨床指導教師證書 (醫檢教字 基109-00015號)

研究計劃

  • 台灣愛滋病患者常用中藥於抗高脂血作用與病毒潛伏細胞活化之活性分析、相關天然藥物研究與機轉探討(106-2320-B-039 -017 -MY3)(共同計畫主持人)
  • 研究特發性炎症肌病相關之嶄新自體抗體(DMR-108-123) (計畫主持人)
  • 膠原血管疾病難治性肺間質疾病之細胞治療(DMR-CELL-17008) (共同計畫主持人)
  • 研究MDA5在特發性炎症肌炎的免疫病理之角色(II)(MOST 106-2314-B-039 -028 -MY2) (計畫主持人)
  • 進行性全身硬化症自體抗體亞群的miRNA與免疫調控之研究以及中藥對其之影響(生醫與醫才轉譯加值人材培育ANCHOR UNIVERSITY子計畫案) (共同計畫主持人)
  • 研究MDA5在無肌病型皮肌炎的分子機轉(MOST 105-2314-B-039-015) (計畫主持人)
  • 自體炎症基因之檢測(精準醫療群體計畫) (共同計畫主持人)
  • 早發性骨關節炎基因之檢測(精準醫療群體計畫) (共同計畫主持人)
  • MDA5在特發性炎症肌炎的免疫病理之角色 (MOST 104-2314-B-039-057) (計畫主持人)
  • 反覆性風濕症病患在發作期(active episode)與間隔期(intercritical period)中免疫細胞和細胞素/趨化素的動態變化之研究(DMR-104-112) (計畫主持人)

榮譽

  • Best Poster Award, 2018 15th International Conference on Immunology (Theme: Spreading the new trends in Immunology), Vienna, Austria.
  • Best Poster Award, 2014 NHRI research day poster competition, Miaoli, Taiwan.
  • Best Poster Award, 2013 International Conference of Inflammation, Cardiometabolic Diseases and Cancer poster competition, Miaoli, Taiwan.
  • Best Poster Award, 2014 NHRI research day poster competition, Miaoli, Taiwan.
  • Best Poster Award, 2013 International Conference of Inflammation, Cardiometabolic Diseases and Cancer poster competition, Miaoli, Taiwan.
  • Best Poster Award, 2013 NHRI research day poster competition, Miaoli, Taiwan.
  • Best Poster Award, 2011 NHRI research day poster competition, Miaoli, Taiwan.
  • Travel Bursary, 2010 The 14th International Congress of Immunology, Kobe, Japan
  • Best Poster Award, 2010 the 18th Symposium on Recent Advances in Cellular and Molecular Biology poster competition, Kenting, Taiwan
  • The First Place in Oral Presentation, 2007 International Conference on Cellular Responses to DNA damage, Hsinchu, Taiwan
  • The First Prize with Excellent in the Best Poster Contest, 2006 College of Life Science, National Tsing Hua University poster and paper competition, Hsinchu, Taiwan
  • Scholarship, 2001 Foundation for the Advancement of Outstanding Scholarship
  • Award, 2000 Veterans General Hospital, National Yang Ming University and National Tsing Hua University (VGH-NYMU-NTHU) project, Taipei Veterans General Hospital, Taiwan
  • The Phi Tau Scholastic Honor Society of the Republic of China, M.S. 1999
  • Award, 1997 Taiwan Society of Laboratory Medicine

國際SCI雜誌發表

  • Li J.-P., Huang H-C, Yang P-J, Chang C-Y, Chao Y-H, Tsao T -Y, Huang H, Hung Y-C, Hsieh M-J, Yang S-F. (2020). FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan. Int. J. Environ. Res. Public Health, 17(16):5694.
  • Chuang T-Y, Li, J.-P., Weng T-F, Wu K-H, Chao Y-H (2020). Combined chelation with high-dose deferiprone and deferoxamine to improve survival and restore cardiac function effectively in patients with transfusion-dependent thalassemia presenting severe cardiac complications. Annals of Hematology.
  • Tsai, F. J. Yang, P. Y. Chen, C. J. Li, Li, J.-P., T. M. Chiou, J. S. Cheng, C. F. Chuang, P. H. Lin, T. H. Liao, C. C. Huang, S. M. Ban, B. Liang, W. M. Lin, Y. J. (2020). Decreased overall mortality rate with Chinese herbal medicine usage in patients with decompensated liver cirrhosis in Taiwan. BMC Complement Med Ther, 20(1):221.
  • Ho YJ, Li, J.-P., Fan CH, Liu HL, Yeh CK (2020). Ultrasound in tumor immunotherapy: Current status and future developments. J Control Release, 323:12-23.
  • Li J.-P., Hsieh MJ, Chou YE, Chao YH, Tsao TC, Yang SF (2020). CD44 Gene Polymorphisms as a Risk Factor for Susceptibility and Their Effect on the Clinicopathological Characteristics of Lung Adenocarcinoma in Male Patients. Int J Environ Res Public Health, 17(9).
  • Wu KH, Cheng CC, Li, J.-P., Weng TF, Yang SF, Pan HH, Chao YH (2020). Toll-like receptor signalling associated with immunomodulation of umbilical cord–derived mesenchymal stem cells in mice with systemic lupus erythematosus. Lupus, 29(2):165-175.
  • Chen P-K, Lan J-L, Li, J.-P., Chang C-K, Chang S-H, Huang P-H, Yeo K-J, Chen D-Y (2020). Elevated plasma galectin-3 levels and their correlation with disease activity in adult-onset Still’s disease. Clinical Rheumatology, 39:1945–1952.
  • Hsu Y-A, Chang C-Y, Lan J-L, Li, J.-P., Lin H-J, Chen C-S, Wan L, Liu F-T (2020). Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells. Journal of Biomedical Science, 27(1):24.
  • Chang CY, Chen CH, Chen YM, Hsieh TY, Li, J.-P., Shen MY, Lan JL, Chen DY (2019). Association between Negatively Charged Low-Density Lipoprotein L5 and Subclinical Atherosclerosis in Rheumatoid Arthritis Patients. J Clin Med, 8(2).
  • Tang KT, Hsieh TY, Chao YH, Li, J.-P., Lan JL, Lin CC, Chen DY (2019). Apoptosis in patients with primary antiphospholipid antibody syndrome. Int J Rheum Dis, 22(4):677-685.
  • Yang C. A., Li, J.-P., Yen J. C., et al. lncRNA NTT/PBOV1 Axis Promotes Monocyte Differentiation and Is Elevated in Rheumatoid Arthritis. Int. J. Mol. Sci. (2018): 19.
  • Tsai, F. J., M. W. Ho, C. H. Lai, C. H. Chou, J.-P. Li, et al. Evaluation of Oral Antiretroviral Drugs in Mice With Metabolic and Neurologic Complications. Front Pharmacol. (2018) 9: 1004.
  • Tsai, F. J., T. M. Li, C. F. Cheng, Y. C. Wu, C. H. Lai, T. J. Ho, X. Liu, H. Tsang, T. H. Lin, C. C. Liao, S. M. Huang, J.-P. Li, et al. Effects of Chinese herbal medicine on hyperlipidemia and the risk of cardiovascular disease in HIV-infected patients in Taiwan. J. Ethnopharmacol (2018) 219: 71-80.
  • Li, T. M., Y. H. Yu, F. J. Tsai, C. F. Cheng, Y. C. Wu, T. J. Ho, X. Liu, H. Tsang, T. H. Lin, C. C. Liao, S. M. Huang, J.-P. Li, J. C. Lin, C. C. Lin, W. M. Liang* and Y. J. Lin*. Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan. J. Ethnopharmacol (2018) 213: 92-100.
  • Tsai, F.-J., Cheng, C.-F., Lai, C.-H., Wu Y.-C., Ho, M.-W., Wang, J.-H., Tien, N., Liu, X., Tsang, H., Lin, T.-H., Liao, C.-L., Huang, S.-M., Li, J.-P., et al. Effect of Antiretroviral Therapy Use and Adherence on the Risk of Hyperlipidemia among HIV-Infected patients, in the Highly Active Antiretroviral Therapy Era. Oncotarget (2017) 8, 106369-106381.
  • Huang, K. C., T. M. Li, X. Liu, J. H. Chen, W. K. Chien, Y. T. Shiao, H. Tsang, T. H. Lin, C. C. Liao, S. M. Huang, J.-P. Li, et al. KCNQ1 variants associate with hypertension in type 2 diabetes and affect smooth muscle contractility in vitro. J. Cell Physiol. (2017) 232(12): 3309-3316.
  • Tsai, F. J., T. M. Li, C. H. Ko, C. F. Cheng, T. J. Ho, X. Liu, H. Tsang, T. H. Lin, C. C. Liao, J.-P. Li, et al. Effects of Chinese herbal medicines on the occurrence of diabetic retinopathy in type 2 diabetes patients and protection of ARPE-19 retina cells by inhibiting oxidative stress. Oncotarget (2017) 8 (38): 63528-63550.
  • Tsai, F. J., T. J. Ho, C. F. Cheng, X. Liu, H. Tsang, T. H. Lin, C. C. Liao, S. M. Huang, J.-P. Li, et al. Effect of Chinese herbal medicine on stroke patients with type 2 diabetes. J. Ethnopharmacol (2017) 200: 31-44.
  • Tsai, F. J., T. J. Ho, C. F. Cheng, Y. T. Shiao, W. K. Chien, J. H. Chen, X. Liu, H. Tsang, T. H. Lin, C. C. Liao, S. M. Huang, Li, J.-P., et al. Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts. Oncotarget (2017) 8:15470-89.
  • Chen DY, Li, J.-P., Chen YM, et al. Rising levels of neopterin increase risk of tuberculosis in rheumatoid arthritis patients with QuantiFERON conversion during biologic therapy. PLoS ONE (2016) 11(11): e0166301.
  • Lai,C.-H.*, Huang,J.-C., Chuan, C.-N., Li, J.-P.., Wu, L.-T., Wu, H.-S., Sun, Y.-C., Lin, M.-L., Lee, J.-F., and Lin, H.-J.* (2016) Mixed Infections of Helicobacter pylori Isolated from Patients with Gastrointestinal Diseases in Taiwan. Gastroenterology Research and Practice (2016) Article ID 7521913
  • Chuang, H.-C., Chen, Y.-M., Hung, W.-T., Li, J.-P., Chen, D.-Y.*, Lan, J.-L.*, and Tan, T.-H.* Downregulation of the phosphatase JKAP/DUSP22 in T Cells as a potential new biomarker of systemic lupus erythematosus nephritis. Oncotarget (2016) 5, 11419.
  • Hsu, C.-P., Chuang, H.-C., Lee, M.-C., Tsou, H.-H., Lee, L.-W., Li, J.-P., and Tan, T.-H.* GLK/ MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer. Oncotarget (2016) 7(27): 41748-41757.
  • Lin, Y.-J., Ho, T.-J., Yeh, Y.-C.,Cheng, C.-F., Shiao, Y.-T., Wang, C.-B. , Chien,W.-K., Chen, J.-H., Liu, X., Tsang,H., Lin, T.-H., Liao, C.-C., Huang, S.-M., Li, J.-P., et al. Chinese Herbal Medicine Treatment Improves the Overall Survival Rate of Individuals with Hypertension among Type 2 Diabetes Patients and Modulates In Vitro Smooth Muscle Cell Contractility. PLoS ONE (2015) 10(12): e0145109.
  • Lin, Y.-J., Chang, J.-S., Liu, X., Tsang, H., Chien, W.-K., Chen, J.-H., Hsieh, H.-Y., Hsueh, K.-C., Shiao, Y.-T., Li, J.-P., et al. Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan. Scientific Report (2015) 5: 14762.
  • Tsou, Y.-A., Lin, C.-D., Hsu, H.-Y., Peng, M.-T., Kuo, Y.-Y., Tien, N., Li, J.-P., Wang, C.-K., Wu, H.-S., Tsai, M.-H., Chen, C.-M., and Lai, C.-H.* (2015) Association of β-Lactam-Sensitive Haemophilus influenzae Type B with Adenoid Biofilm Formation in Patients with Adenoidectomy Surgery. Surg. Infect. (Larchmt) (2015) 16(6): 709-715.
  • Chuang, H.-C., Sheu, W., Lin, Y.-T., Tsai, C.-Y., Yang, C.-Y., Cheng, Y.-C., Huang, P.-Y., Li, J.-P., Chiu, L.-L., Wang, X., Xie, M., Schneider, M., and Tan, T.-H.* HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nat. Comms. (2014, Aug) 5: 4602.
  • Li, J.-P., Yang, C.-Y., Chuang, H.-C., Lan, J.-L., Chen, D.-Y., Chen, Y.-M., Wang, X., Chen, A. J., Belmont, J. W., and Tan, T.-H.* The phosphatase JKAP/DUSP22 inhibits T-cell receptor signaling and autoimmunity by inactivating Lck. Nat. Comms. (2014, Apr) 5: 3618. [Major publication]
  • Yang, C-Y, Li, J.-P., Chiu, L.-L., Lan, J.-L., Chen, D.-Y., Chuang, H.-C., Huang, C.-Y., and Tan, T.-H.* Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates T-cell receptor signaling by inhibiting TAB1 activation. J. Immunol. (2014, Feb) 192:1547-1557.
  • Wang, X., Li, J.-P., Chiu, L.-L., Lan, J.-L., Chen, D.-Y., Booomer, J., and Tan, T.-H.* Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein. J. Biol. Chem. (2012, Aug) 287:34091-34100. (Co-first author)
  • Wang, X., Chuang, H.-C., Li, J.-P., and Tan T.-H.* Regulation of PKC-θ function by phosphorylation in T-cell receptor signaling. Frontiers in Immunology. (2012, Jul) 3: 197.
  • Wang, X, Li, J.-P., Kuo, H.-K., Chiu, L.-L., Dement, G. A., Lan, J.-L., Chen, D.-Y., Yang, C.-Y., Hu, H., and Tan, T.-H.* Downregulation of B-cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of the activated BLNK. J. Biol. Chem. (2012, Feb) 287:11037-11048.
  • Chuang, H.-C., Lan, J.-L., Chen, D.-Y., Yang, C.-Y., Chen, Y.-M., Li, J.-P., Huang, C.-Y., Liu, P.-E., Wang, X., and Tan, T.-H.* The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Nat. Immunol. (2011, Oct) 12:1113-8.
  • Li, J.-P., Fu, Y.-N., Chen, Y.-R., and Tan, T.-H.* JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J. Biol. Chem., (2010, Feb) 285: 5472-5478.
  • Li, J.-P., Wang, C.-Y., Tang, Y.-A, Lin, Y.-W., and Yang, J.-L.* Role of ERK signaling in nucleotide excision repair and genotoxicity in response to As(III) and Pb(II). Pure and Applied Chemistry, (2008) 80, 2735-2750.
  • Li, J.-P. and Yang, J.-L.* Cyclin B1 Proteolysis via p38MAPK signaling participates in G2 checkpoint elicited by arsenite. J. Cell. Physiol. (2007) 212, 481-488.
  • Li, J.-P., Lin, J.-C., and Yang, J.-L.* ERK Activation in Arsenite-Treated G1-Enriched CL3 Cells Contributes to Survival, DNA Repair Inhibition, and Micronucleus Formation. Toxicol. Sci., (2006) 89, 164-172.
  • Hsiue, G.-H., Wang, C.-H., Lo, C.-L., Wang, C.-H., Li, J.-P., and Yang, J.-L.* Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)--poly(l-lactide) diblock copolymer for application in drug delivery. Int. J. Pharm. (2006) 317, 69-75.

國際會議發表

  • Li, J.-P., S.-H. Chang, Gregory J. Tsay, D.-Y. Chen, and J.-L. Lan*. (2019) Idiopathic inflammatory myopathy patients with different autoantibody exhibit unique peripheral blood T cell subsets. (AAI Annual Meetings. IMMUNOLOGY 2019. San Diego, California, May 9–13, 2019.)
  • Li, J.-P., Lan, J.-L.* (2018) Dysregulated immune system in MDA5-positive dermatomyositis patients. (15th International Conference on Immunology, Vienna, Austria. July 05 - 07, 2018) [Poster Award]
  • Li, J.-P., Yang, C.-Y., Chuang, H.-C., Chen, D.-Y., Chen, Y.-M., Hung, W.-T., Lan, J.-L., and Tan, T.-H.* (2013) The phosphatase JKAP inhibits T-cell receptor signaling and autoimmunity by inactivating Lck. (International Conference on Inflammation, Cancer, and Metabolic Syndrome, Taipei, Taiwan, November 4-6, 2012) [Poster Award]
  • Li, J.-P., Yang, C.-Y., Chuang, H.-C., and Tan, T.-H.* (2012) Downregulation of TCR Signaling and Autoimmunity by JKAP through Lck Inactivation. (IBMS / NHRI Joint International Conference on Inflammation, Cancer, and Metabolic Syndrome, Taipei, Taiwan, November 1-3, 2012) [Oral Presentation]
  • Li, J.-P., Chen, Y.-R., Tan, T.-H.* (2010) JNK Pathway-associated Phosphatase (JKAP/DUSP22) Suppresses T-Cell Receptor Signaling through Dephosphorylation of Lck and ZAP-70. (14th International Congress of Immunology, Kobe, Japan, August 22-27, 2010) [Travel Bursary]
  • Li, J.-P., Fu, Y.-N., Chen, Y.-R., Tan, T.-H.* (2009) JKAP dephosphorylates FAK and suppresses cell migration. (The 12th SCBA International Symposium, Taipei, Taiwan, June 15-18, 2009)
  • Li, J.-P. and Yang, J.-L.* (2007) Cyclin B1 Proteolysis via p38MAPK signaling participates in G2 checkpoint elicited by arsenite. (International Conference on Cellular Responses to DNA damage. Hsinchu, Taiwan, April 26-28, 2007) [First Place in Oral Presentation]
  • Tang, Y.-A., Li, J.-P., and Yang, J.-L.* (2007) Involvement of lysosomal proteases in Skp2 proteolysis elicited by arsenite. (Symposium of Protein Modification by SUMO, Ubiquitin and Nedd8 (SUN), Institute of Biomedical Sciences, Academia Sinica, November 15-16, 2007)
  • Tang, Y.-A., Li, J.-P., and Yang, J.-L.* (2007) Arsenite-elicited Skp2 proteolysis requires leupeptin-sensitive proteases and APC/CCdh1 but not 26S proteasome (Cell Stress Chaperones online 12: 2M_01_P; 2nd World Conference of Stress, Budapest, Hungary, August 23–26, 2007)
  • Li, J.-P., and Yang, J.-L.* (2006) p38 MAPK signaling triggers premature cyclin B1 proteolysis and links G2 arrest and apoptosis after arsenite exposure (The FASEB Summer Research Conference: Ubiquitin & Cellular Regulation, Saxtons River, Vermont, USA, July 22 - 27, 2006)
  • Li, J.-P., Lin, J.-C., and Yang, J.-L.* (2005) ERK activation in arsenite-treated G1 cells contributes to cell-cycle re-entry, survival, DNA repair inhibition, and micronucleus formation. The FASEB Summer Research Conference, Protein kinases and protein phosphorylation. Snowmass Village, Colorado, July 16-21, 2005.
  • Li, J.-P., Yen, A.-H., and Yang, J.-L.* (2001) Overexpression of APE/Ref-1 antisense gene prolongs mitotic phase and sensitizes cells to apoptosis induced by cadmium. Mutation Research 483 (Suppl. 1) S138. (8th International Conference on Environmental Mutagens. Shizuoka, Japan, October 21-26, 2001)
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